Edible Medicinal And Non-Medicinal Plants: Volume 7

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Considerable attention has been focused on sulforaphane (SF), a phytochemical from broccoli possessing anticancer Cancer Therapy: Preclinical Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells Yanyan Li1,3, Tao Zhang1, Hasan Korkaya2, Suling Liu2, Hsiu-Fang Lee1, Bryan Newman1, Yanke Yu1, Shawn G. Clouthier 2, Steven J. Schwartz3, Max S. Wicha , … Certain phytochemicals, in particular curcumin, epigallocatechin-3-gallate (EGCG), sulforaphane, resveratrol and genistein have been shown to interfere with these intrinsic CSC pathways in vitro and in human xenograft mice, leading to elimination of CSCs. cells capable of extensive self-renewal that contribute to metastasis and treatment resistance. Sorafenib (SO) is a promising new multikinase inhibitor for treatment of advanced kidney and liver cancers. We report here targeting of pancreatic cancer stem cells (CSC) by SO and the development of a strategy to enhance this effect. 2012-03-12 Sulforaphane blocks a special metabolic pathway In the cancer stem cells.

Sulforaphane cancer stem cells

Sulforaphane reduces YAP/∆Np63α signaling to reduce cancer stem cell survival and tumor formation. Fisher ML(1), Ciavattone N(1), Grun D(1), Adhikary G(1), Eckert RL(1)(2)(3)(4). Author information: (1)Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA. Sulforaphane Inhibits Gastric Cancer Stem Cells via Suppressing Sonic Hedgehog Pathway - PubMed. Sulforaphane (SFN) is the major component extracted from broccoli/broccoli sprouts. It has been shown to possess anti-cancer activity.

Herr I., Rausch V. (2012) Sulforaphane as New Therapeutic Agent for Targeting of Cancer Stem Cells with Focus to Prostate and Pancreatic Cancer. In: Hayat M. (eds) Stem Cells and Cancer Stem Cells, Volume 7. Recent evidence suggests that pancreatic cancer and other solid tumors contain a subset of tumorigenic cells capable of extensive self-renewal that contribute to metastasis and treatment resistance.

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The objective of this work was to evaluate the inhibitory effect of SFN on gastric cancer by Sonic hedgehog (Hh) Pathway. … Li, S. H. et al. Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.

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We herein report that sulforaphane (SFN), a potent anti-cancer and well-tolerated dietary compound, inhibits cancer stem-like cell (CSC) properties and enhances therapeutic efficacy of cisplatin in human non-small cell lung cancer (NSCLC). SFN exerted these functions through upregulation of miR-214, which in turn targets the coding region of c-MYC. Sulforaphane reduces YAP/∆Np63α signaling to reduce cancer stem cell survival and tumor formation. Fisher ML(1), Ciavattone N(1), Grun D(1), Adhikary G(1), Eckert RL(1)(2)(3)(4). Author information: (1)Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA. Sulforaphane Inhibits Gastric Cancer Stem Cells via Suppressing Sonic Hedgehog Pathway - PubMed.

It has been shown to possess anti-cancer activity. Gastric cancer is common cancer worldwide. The objective of this work was to evaluate the inhibitory effect of SFN on gastric cancer by Sonic hedgehog (Hh) Pathway. … Li, S. H. et al. Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. Molecular and cellular biochemistry 373, 217–227 (2013).
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Curr Med Chem. 2020 Feb 27. doi: 10.2174/0929867327666200228110738. pancreatic cancer, agents that cure this highly resis-tant and metastasizing disease are not available.

Gastric cancer is common cancer worldwide. The objective of this work was to evaluate the inhibitory effect of SFN on gastric cancer by Sonic hedgehog (Hh) Pathway. … Li, S. H. et al.
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2012-11-06 Sulforaphane (SFN) has been indicated for the prevention and suppression of tumorigenesis in solid tumors. Herein, we evaluated SFN’s effects on imatinib (IM)-resistant leukemia stem cells (LSCs). CD34+/CD38– and CD34+/CD38+ LSCs were isolated from KU812 cell line flowcytometrically. Isolated LSCs showed high expression of Oct4, CD133, β-catenin, and Sox2 and IM resistance. Apoptosis-resistant cancer stem cells (CSCs) have been identified in AIPC and are not eliminated by current therapeutics.